Orbitofrontal Cortex Volumes in Patients Diagnosed with Somatic Symptom Disorder

Aim: Somatic symptom disorder (SSD) is a psychiatric with unknown etiopathogenesis that still under investigation. The results of neuroimaging studies on SSD have shown some brain regions may be associated it. In this connection, study aims to explore the orbitofrontal cortex (OFC) morphometric changes in patients better comprehend etiopathogenesis.
 Material and Methods: enrolled 20 healthy controls. All participants were administered sociodemographic clinical questionnaire, Hamilton Depression Rating Scale (HAM-D) Anxiety (HAM-A). volumes total brain, OFC, white matter, gray matter measured by magnetic resonance imaging (MRI)-based method studied patients. 
 Results: Orbitofrontal volume was significantly smaller patient group than controls (p0.05).
 Conclusions: OFC markedly controls, suggesting pathophysiology. Future examining functional features using cognitive function tests will likely shed more light issue.
 Keywords: somatic disorder, volume, cortex, MRI